HORDB

ID: hor002024
Uniprot ID: Q28588
Protein name: GnRH-associated peptide 1
Gene name: GNRH1
Organism: Ovis aries (Sheep)
Family: GnRH family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005183 gonadotropin hormone-releasing hormone activity
GO BP: GO:0007165 signal transduction; GO:0033684 regulation of luteinizing hormone secretion; GO:0046880 regulation of follicle-stimulating hormone secretion
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Mechanism: NA
Cross BBB: NA
Target: GNRHR
Target Unid: P32237
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002024_AF2.pdb

hor002024_ESM.pdb

Mass:	614260	Formula:	C229H374N64O74S3
Absent amino acids:	MTWY	Common amino acids:	E
pI:	4.88	Basic residues:	7
Polar residues:	10	Hydrophobic residues:	17
Hydrophobicity:	-26.88	Boman Index:	-7963
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	97.5
Instability Index:	6268.54	Extinction Coefficient cystines:	125
Absorbance 280nm:	2.66